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Pharmacology: Mechanism of action: Adapalene acts on retinoid receptors. Mechanistically, Adapalene binds to specific Retinoic acid nuclear receptors but it does not bind to the cytosolic receptor protein. Although the exact mode of action of Adapalene is unknown, it is suggested that topical Adapalene normalizes the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.
Benzoyl Peroxide is an antibacterial agent which is believed to act by oxidizing proteins, including bacterial proteins, and reducing the population of Propionibacterium acnes which are usually abnormally present in the acne-affected pilosebaceous unit. Therefore, Adapalene and Benzoyl Peroxide act through different, but complementary, mechanisms that affect different aspects of acne therapy.
